Comparative Study of ALT, AST, GGT & Uric Acid Levels in Liver Diseases

Abstract

Hepatic injury is associated with distortion of the metabolic function. Hepatic disease/Cirrhosis of liver can be evaluated by biochemical analysis of serum tests, includes levels of serum Alanine and Aspartate amino transferases, Alkaline Phosphatase, and also by Uric Acid estimation. The present study was continued to assay liver associated enzymes on patients with cirrhosis of liver, Amoebic liver abscess and hepatitis and to find out the comparative levels of enzymes and uric acid among the groups. In this study total 80 male subjects ( 25 healthy controls and 55 patients as case groups) aged between 20 to 60. yrs. Was enrolled. One case group consists 25 male patients(cirrhosis of liver) and second case group consists of 15 male patients (Amoebic liver abscess disease) and third case group consists of 15 male patients ( Hepatitis ) suffering from corresponding diseases ad controls group subjects are 25 in number. ALT, AST, ALP,GGT and uric acid levels are estimated in the above groups by standard methods. Several folds of variations in the analysed enzymes were found between healthy controls and case groups. There is a significant elevation in the Uric acid levels comparatively with controls group. Comparitive elevation of serum associated enzymes were observed to indicate the degree of hepatic damage in cirrhosis, amoebic abscess of liver diseases and hepatitis. Data analysed using SPSS software.