Comparative study of 6-chloropurine and 6-mercaptopurine in acute leukemia in adults.

Abstract

Article1 August 1959COMPARATIVE STUDY OF 6-CHLOROPURINE AND 6-MERCAPTOPURINE IN ACUTE LEUKEMIA IN ADULTSROSE RUTH ELLISON, RICHARD T. SILVER, RALPH L. ENGLE JR.ROSE RUTH ELLISONSearch for more papers by this author, RICHARD T. SILVERSearch for more papers by this author, RALPH L. ENGLE JR.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-51-2-322 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONThe results of comparing two consecutive series of adults with acute leukemia treated either with 6-mercaptopurine (6MP) or 6-chloropurine (6CP)1suggested that both drugs behave similarly in many respects (table 1). That the action of these drugs would be similar in the human was suggested by their effect on transplanted Sarcoma 180 in mice, and by the resistance to 6CP of a 6MP-resistant strain of Sarcoma 180,2even though 6CP is without significant effect in most strains of mouse leukemia.3Nevertheless, a slightly increased frequency of remission and longer median survival time were observed in the group of adults...Bibliography1. EllisonKarnofskyBurchenal RRDAJH: Clinical evaluation of 6-chloropurine in leukemia of adults, Blood 13: 705-724, 1958. CrossrefMedlineGoogle Scholar2. ClarkePhilipsSternbergStock DAFSSSCC: Effects of 6-mercaptopurine and analogs on experimental tumors, Ann. New York Acad. Sc. 60: 235, 1954. CrossrefMedlineGoogle Scholar3. Burchenal JH: Unpublished data. Google Scholar4. : Criteria for the evaluation of response to treatment in acute leukemia, Blood 11: 676, 1956. Google Scholar5. Tivey H: The natural history of untreated acute leukemia, Ann. New York Acad. Sc. 60: 322, 1954. CrossrefMedlineGoogle Scholar6. HautAltmanCartwrightWintrobe ASJGEMM: The influence of chemotherapy on survival in acute leukemia, Blood 10: 875, 1955. CrossrefMedlineGoogle Scholar7. Bross IJ: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication October 16, 1958.From the Chemotherapy Service, Department of Medicine, Memorial and James Ewing Hospitals; Department of Medicine, New York Hospital, Cornell University Medical Center; and the Division of Clinical Chemotherapy, Sloan-Kettering Institute, New York, N. Y.These studies were supported by research grants C 1889, CY 3215 and CY 3062 from the National Cancer Institute, U. S. Public Health Service, by a grant from the American Cancer Society and the Damon Runyon Memorial Fund for Cancer Research, and institutional grants from the Lasker Foundation, the Grant Foundation and the Black-Stevenson Fund.Requests for reprints should be addressed to Rose Ruth Ellison, M.D., Memorial Center for Cancer and Allied Diseases, 444 East Sixty-eighth Street, New York 21, N. Y. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byLeukemic Cellular Proliferation: A PerspectiveHepatic and pancreatic damage produced by cytotoxic drugsAcute Nonlymphocytic Leukemia in the Elderly: Biology and TreatmentCombination Chemotherapy of Adult Acute Nonlymphoblastic LeukemiaJ. A. LEVI, M.B., P. C. VINCENT, M.B., F. W. GUNZ, M.D., Ph.D.6-MercaptopurineIntrahepatic Cholestasis Due to AzathioprineTreatment of adult acute leukemia with arabinosylcytosine and thioguanineTreatment of Acute LeukemiaEDWARD S. HENDERSON, M.D.Inactivation of guanosine 5'-phosphate reductase by 6-chloro-, 6-mercapto-, and 2-amino-6-mercapto-9-β-D-ribofuranosylpurine 5'-phosphatesMENINGEAL INVOLVEMENT IN ACUTE LEUKAEMIA OF ADULTS, WITH A REPORT ON A PATIENT TREATED BY METHOTREXATE INTRATHECALLY ADMINISTEREDConversion of 6-chloropurine to its ribonucleotide by ascites tumor cellsHepatic fibrosis in a child possibly due to prolonged methotrexateCombination Therapy of Adult Acute Myelogenous LeukemiaMetabolic Basis for the Actions of Analogs of Purines and PyrimidinesDrug Fever Produced by Six-mercaptopurineARTHUR SAWITSKY, M.D., JAVID RUOHANI, M.D., ROBERT N. LEVY, M.D.Die Therapie der Leukämien im KindesalterReactions of Ribonucleotide Derivatives of Purine Analogues at the Catalytic Site of Inosine 5'-Phosphate DehydrogenaseAcute leukemia in the adult male.II. Natural historyDie Therapie der Leukämien im KindesalterManagement of Reticuloendothelial MalignanciesKlinische und therapeutische Probleme der akuten Leukämie beim ErwachsenenThe clinical management of leukemia 1 August 1959Volume 51, Issue 2Page: 322-338KeywordsCancer chemotherapyChemotherapyDrugsHospital medicineResearch designResearch fundingResearch grantsSarcomaStatistical dataSurvival analysis Issue Published: 1 August 1959 PDF downloadLoading ...