Comparative study in acute pancreatitis to find out the effectiveness of early addition of ulinastatin to current standard care in Indian subjects

Abstract

Background: Acute pancreatitis is an inflammatory condition of the pancreas which begins in pancreatic acinar cells and triggers local inflammation that may progress to systemic inflammatory response (SIRS) causing distant organ involvement and hampering its function and ending up with multiple organ dysfunction syndrome (MODS). It remains a common disorder with devastating consequences .Although most episodes are mild and self-limiting, up to a one-fifth of patients develop a severe attack that can be fatal. Inspite of technical advances in medical and surgical field’s acute pancreatitis remains a major cause of morbidity and mortality. Aims and Objectives: Our aim is to find out the effectiveness of early addition of Ulinastatin to current standard care in Indian subjects with acute pancreatitis. The aim of this study is to compare effectiveness of with or without injection Ulinastatin in acute pancreatitis with respect to: 1) Duration of analgesic requirement, 2) Prevention of early sepsis and complication, 3) Duration of hospital stay. Material and methods: This prospective study was conducted between December 2018 to December 2019 on patients admitted to Dhiraj Hospital Piparia Vadodara. 60 patients with episodes of acute pancreatitis were enrolled for the study.