Comparative study chromatographic fractions activities from Terminalia ivorensis and Ketoconazole as standard antifungal on Trichophyton mentagrophytes var. interdigitale in vitro growth.

Abstract

The present study was undertaken to evaluate in-vitro antimicrobial activity of Ketoconazole and extracts from trunk’s barks of Terminalia ivorensis A. Chev (Combretaceae). In vitro antimicrobial activity of all the extracts was done by agar slant. Extracts were incorporated in Sabouraud medium culture and extract has been inserted to this medium according to the Agar slant method and Ketoconazole were used as standards for antifungal assay. Antimicrobial activity was determined by diminution of mushroom in the assay tubes. For each extract five tests were done. The antifungal activity was more pronounced against Trichophyton mentagrophytes var. interdigitale. The fraction F8 showed best antifungal activity. T. ivorensis barks extracts showed better antifungal activity than commercially used antibiotics. Demonstration of antimicrobial activity of T. ivorensis provides the scientific basis for the use of this plant in the traditional treatment of diseases and may help to discover new chemical classes of antibiotic substances that could serve as selective agents for infectious and cutaneous diseases. This investigation has opened up the possibility of the use of this plant in drug development for human consumption possibly for the treatment of various infections caused by opportunists’ mushrooms.