Comparative study between Ranson's scoring system and C reactive protein analysis in predicting the severity of acute pancreatitis

Abstract

Background: Acute pancreatitis is a self-limiting disease process which when diagnosed at the primary stages helps us manage the condition with utmost care, however in severe cases it has been deemed to be one of the most common lethal conditions. The various prognostic indicators to predict the severity of the acute pancreatitis includes Ranson, modified Glasgow, MOSS, CT severity index, Apache II scoring systems and biochemical markers like C-reactive protein (CRP), IL 6 and serum prolactin level. Methods: A total of 50 patients with clinical diagnosis of acute pancreatitis were studied at the Sri Siddhartha institute of medical sciences and research centre during the period of October 2019 to September 2021. We assessed the Ranson’s score as well as the CRP levels in the patients at 24, 48 and 72 hours respectively. Results: In this study, 47 patients were male and only 3 were females. The patients with the Ranson’s score of 2 or <2, 3-4, 5 or >5 were seen in 21, 22 and 7 cases respectively. Further, the mean ± SD level of CRP at 24, 48 and 72 hours was 120.348±47.51, 134.926±47.26 and 146.57±44.43 respectively. It was found to be statistically significant. We report 8% mortality rate in our study. Conclusions: Our study showed that both CRP as well as Ranson’s score is good predictors of the disease process. Ranson’s score was a one-time assessment of the disease severity of acute pancreatitis, while CRP levels showed a concurrent increase in the CRP levels after each 24 hour interval which reflects the increased progression of the disease process with time at the initial stage of acute pancreatitis.