Comparative study between irisin and donepezil (Anticholinesterase) on cognitive functions in cases of scopolamine induced Alzheimer’s disease

Abstract

Introduction: Alzheimer's disease (AD) is a progressive neurological disorder. Donepezil hydrochloride is a cholinesterase inhibitor that is selective. Irisin is a 112-amino acid glycosylated protein-hormone. Objective: to compare the effect of irisin and donepezil (anticholinestrase) on cognitive function in cases of scopolamine induced Alzheimer’s disease like condition in male albino rats. Materials and methods: Fifty albino male rats of a local strain, weighing between 150 and 200 g, enrolled in this study. At room temperature, with 12-hour light/dark cycles, and with free access to running tap water and pelleted laboratory chow, the rats were kept in separate cages (5 rats per cage) for the duration of the experiment. Results: Donepezil administration achieved significant decrease in A che level in donepezil treated group, in relation to AD group, (AD+D). Irisin administration caused insignificant change in A che level in Irisin treated group in relation to AD group (AD+I). Conclusions: Irisin can reduce scopolamine-induced AD manifestations through its antiinflammatory, antioxidant and antiapoptotic effects, which were evaluated both biochemically and behavioural. Donepezil enhances memory as it is anti cholinestrase, also it has anti-inflammatory effect. Donepezil and irisin treatment potentiate each other as they act synergestically by different mechanisms to counrtact memory loss.