Abstract
Periodontitis is a chronic disease characterized by bone loss and inflammatory changes. We studied the effect of a homeopathic agent (Mercúrios Corrosivos 6 CH) and a non-steroidal anti-inflammatory drug (nimesulide) on the alveolar bone loss progression in experimentally induced periodontitis in rats. Sixty (60) Wistar rats were separated into group 1 (homeopathy), group 2 (nimesulide) and group 3 (saline solution). Silk ligatures were placed at the gingival margin level of the lower right first molar of all rats. Alveolar bone loss was evaluated by light microscopic analysis and analyzed using software Image J. The results were submitted to the analysis of variance (ANOVA) and Tukey’s posttest (p
Highlights
Introduction anti-inflammatory, Inflammatory periodontal disease represents the most important cause of tooth loss in adults (ARMITAGE, 1999; KANTARCI; VAN DYKE, 2005; HORTZ; CONRADS, 2007)
It has been suggested that therapeutic benefits resulting from classical non-steroidal antiinflammatory drugs (NSAIDs) use are derived from a COX-2 blockade, whereas a concomitant cyclooxygenase-1 (COX-1) blockade by these drugs provokes side effects (NASSAR et al, 2005)
The rats were anesthetized with Tiopental (Thiopentax®, 60 mg/kg – intraperitoneally) and received surgically a silk thread ligature around the lower right first molar in a submarginal position to induce experimental periodontitis
Summary
Introduction anti-inflammatory, Inflammatory periodontal disease represents the most important cause of tooth loss in adults (ARMITAGE, 1999; KANTARCI; VAN DYKE, 2005; HORTZ; CONRADS, 2007). The pathogenesis of periodontitis involves the presence of a plaque factor that initiates local inflammatory reaction in a predisposed host, provoking edema, cell influx, and release of inflammatory mediators This pathogenesis consists of a cascade of inflammatory and immunological reactions, which have not yet been fully elucidated (CURTIS, 2005; KANTARCI; VAN DYKE, 2005; HORTZ; CONRADS, 2007). Several studies have demonstrated that cyclooxygenase-2 (COX-2) is involved in the pathogenesis of periodontitis (OFFENBACHER; HEASMAN; COLLINS, 1993; LOHINAI et al, 2001) In pathophysiological states, such as in inflammatory reactions, triggering of this inducible isoenzyme, induces the production of great amounts of prostaglandins, like prostaglandins E2, which are important mediators in causing tissue destruction and alveolar bone loss in periodontal disease (WILLIANS et al, 1985; JOUZEAU et al, 1997; BEZERRA et al, 2000). The aim of this study was to compare and evaluate whether homeopathy and nimesulide, a preferential COX-2 inhibitor, alter alveolar bone loss during the progression of experimentally induced periodontitis in rats
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