Abstract
Background and objectivesExtracorporeal shock wave lithotripsy (ESWL) is used safely for management of urinary stones. The aim of this randomized double blinded study was to compare the effects of dexmedetomidine-ketamine and fentanyl-ketamine combinations on analgesia, sedation, hemodynamics and respiratory effects in patients underwent ESWL.MethodsSixty patients aged between 20 and 50 years, ASA I or II physical status were randomly assigned into two groups. In Group Fentanyl-ketamine (FK) (n = 27): Patients received fentanyl at a 1 μg/kg over 10 min before the procedure and 0.5 mg/kg bolus of ketamine. In Group Dexmedetomidine-ketamine DK (n = 30): patients received dexmedetomidine 1 μg/kg over 10 min before the procedure and a 0.5 mg/kg bolus of ketamine. A blinded researcher assessed the patient’s pain level (primary outcome), sedation level, and awareness via visual analogue scale (VAS), modified Observer’s Assessment Alertness/sedation, and bispectral index respectively.ResultsThere was a significant increase in VAS in the recovery period in FK group. There was a significant decrease in hemodynamics (HR, MAP) in the recovery period in DK group. There was a significant increase in bispectral index values in FK group during the postoperative period. The first analgesia required was significantly longer in DK. There was a significant increase in sedation score in the recovery period in FK group. There was no significant difference between the two groups as regards the adverse effects except nausea and vomiting (significant in FK group).ConclusionDexmedetomidine/ketamine combination was accompanied by more prolonged analgesia in the recovery period, prolonged sedation, and delayed request of first dose analgesia with less nausea and vomiting than fentanyl/ketamine combination.
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
