Comparative study between a pSWE and 2D-SWE integrated in the same ultrasound machine taking Transient Elastography as reference method

Abstract

Purpose To evaluate the feasibility and usefulness of two novel elastographic methods, integrated in the same ultrasound machine (Samsung-Medison RS85), one pSWE and one 2D-SWE, for liver fibrosis (LF) assessment using Transient Elastography (TE) as the reference method. Material and methods Our study included 115 subjects, with or without chronic liver disease, in which LF was evaluated in the same session by means of Transient Elastograpy (Fibroscan, EchoSens) and by pSWE and 2D-SWE techniques integrated in the same ultrasound machine (Samsung-Medison RS85 Ultrasound Machine). Reliable liver stiffness (LS) measurements were defined as follows: for TE as the median values of 10 measurements with a success rate of more than 60% and an interquartile range/median ratio (IQR/M) 0.5 and an IQR/M Results Reliable measurements by TE were obtained in 98.2% (113/115), by pSWE in 93.9% (108/115) and by 2D-SWE in 92.1% (106/115) subjects, so the final analysis included 101 patients. We divided the cohort into 3 groups: fibrosis 5.9 kPa (AUROC=0.95, 95% CI (0.89; 0.98), p 8 kPa (AUROC=0.98, 95% CI (0.94; 0.99), p 6.1 kPa (AUROC=0.93, 95% CI (0.86; 0.97), p 7.6 kPa (AUROC=0.98, 95% CI (0.93; 0.99), p Conclusion The novel pSWE and 2D-SWE are feasible methods for assessing liver fibrosis, both techniques strongly correlating with TE results.