Comparative Study about Cytotoxicity with CuO Engineered Nanoparticles, TiO<sub>2</sub> Engineered Nanoparticles, CeO<sub>2</sub> Engineered Nanoparticles, Single-Walled Carbon Nanotubes

Abstract

Engineered nanoparticles have been extensively used in electronics, energy, materials and biomedical areas. Engineered nanoparticles with unique magnetic, luminescent, and catalytic properties can not only benefit human society, but also cause potentially harmful interactions with living systems. This study was aimed at assessing the cytotoxicity of CuO ENPs, TiO2ENPs, CeO2ENPs, SWCNTs in human lung epithelial cell line (A549). Herein, we performed a comprehensive study on the cytotoxicity of four different ENPs by examining the viability of A549 cells. The results showed that CuO ENPs could cause a highest dose-dependent cytotoxicity, SWCNTs were more toxic than TiO2ENPs and CeO2ENPs to A549 cells, TiO2ENPs induced a slight loss of cell viability at 100 mg/L and CeO2ENPs had no obvious cytotoxicity. These effects were dose related, and should be considered in the application of different areas of ENPs.