Abstract
Collagen hydrolysers are three-dimensional polymeric materials with limited cross-linking and high hydrophilicity, having multiple medical applications. The most used collagen is the one extracted from bovine skin, which is now the industrial source of collagen. Due to the outbreak of some threatening diseases such as BSE, transmissible spongiform encephalopathy, foot-and-mouth disease, researchers have sought a safer alternative to collagen. This was the marine resource, which offered multiple opportunities to capitalize on clean sea-water raw material. This paper presents a comparative study of the physico-chemical properties of collagen hydrogels derived from collagen obtained from calf and skin from the Black Sea. Physico-chemical and spectrophotometric analyzes were performed to determine the structure. Studies have been conducted to analyze rheological behavior, antioxidant activity and antimicrobial activity. The total antioxidant capacity (ACL) is higher for collagen mixtures with 40% ethyl alcohol and shows higher values for fish collagen compared to calf collagen. Antimicrobial analysis shows that all collagen hydrogels show antimicrobial activity, both gram-positive (Staphylococcus aureus ATCC 6538P) and gram-negative (Escherichia coli ATCC 10536), which increases with increasing collagen concentrations.
Highlights
Collagen in all its characteristic forms is presented as a polymer that is distinguished by increased hydrophilicity, variable ionic character and diverse functionality, and can be involved in a large number of interaction systems with other micro or macromolecular components [1]
The results of the present study show the physico-chemical characteristics of collagen hydrogels from calf and Gray Mullet skin from the Black Sea
The paper presents physico-chemical characteristics of collagen hydrogels derived from bovine skin compared to collagen extracted from Gray Mullet skin from the Black Sea
Summary
Collagen in all its characteristic forms is presented as a polymer that is distinguished by increased hydrophilicity, variable ionic character and diverse functionality, and can be involved in a large number of interaction systems with other micro or macromolecular components [1]. Collagenic hydrogels are polymeric materials with three-dimensional structure, limited cross-linking and high hydrophilicity that are applied topically. Due to these characteristics, hydrogels can absorb a high amount of water and give the wound a wet environment and at the same time have the ability to absorb the exudates produced by it [21]. Due to the outbreak of menacing diseases such as BSE, transmissible spongiform encephalopathy (FMD), foot-and-mouth disease (FMD), researchers have sought a safer collagen alternative This was the marine resource, which offered multiple possibilities to harness clean raw material if it came from sea-fishing [29-31]. The hydrogels were crosslinked with 10% tannic acid over collagen and maintained at 4 0C for 24 h;
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