Abstract
A low phosphatide content was found in primary hepatoma of rat when compared with normal rat liver. Chromatographic analyses did not reveal, however, remarkable differences in the phosphatide composition of the normal and neoplastic tissue. The ratio of the 32P incorporation in vitro into phosphatidylcholine and phosphatidylethanolamine was lower in normal rat liver than in primary liver tumour. Gas chromatographic analyses of fatty acids performed on total lipid and its different components disclosed also notable differences between hepatoma and normal liver. A significant difference was observed in the stearic acid-oleic acid proportions between phosphatides of rat liver and primary hepatoma. The plasmalogen content of hepatoma was relatively rather high. The comparative analysis of phosphatides was extended to cell fractions obtained by differential centrifugation and to a mitochondrial membrane fragment. Within one tissue the fatty acid composition appeared to be characteristic for the lipid component and was independent of the cell fraction. A similar 32P pattern of the phosphatides from all cell fractions of one tissue was found after an incubation of slices with radioactive phosphate. Consequently the observed differences between phosphatides of normal rat liver and hepatoma are distributed throughout the cells.
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