Abstract
AbstractThe effect of incubation temperature on cell multiplication and on the efficiency of benzpyrene (BP) metabolism to water‐soluble derivatives was compared in cell cultures derived from three poikilothermic and three homeo‐thermic vertebrate species. The fish cells grew optimally at about 20°C and the amphibian and reptilian cells at about 30°C, and in general, these cells multiplied over broader ranges of temperature than the mouse, hamster or chick cells. In each cell system, the maximum temperature supporting efficient BP metabolism exceeded the maximum temperature supporting cell growth by 4 to 8°, but the range of temperatures supporting near‐maximal BP metabolism was also considerably broader in the poikilothermic than in the homeothermic vertebrate cultures.
Published Version
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