COMPARATIVE STUDIES ON REPRODUCTIVE MALE RABBITS AS AFFECTED BY IVERMECTIN OR BOTH OF GARLIC AND CINNAMON OILS TREATMENTS 1. ACARICIDAL EFFICACY OF IVERMECTIN, GARLIC AND CINNAMON OILS AGAINST Sarcoptes scabiei IN SUFFERING INFESTED RABBITS.

Abstract

Thirty-six V-Line male rabbits of ten months age, average weight 3.5 kg were used. They were allocated randomly into six equal groups. First and second were served as a negative (NC) and positive (PC) control, third group was injected by double therapeutic dose (DTD) 1mg/kg body weight of ivermectin via subcutaneous injection, fourth groupwas treated with 5% garlic oil (GO), fifth group was treated with 5% cinnamon oil (CO), while, sixth group was treated with 5% garlic oil + 5% cinnamon oil mixture (MO). Groups were treated GO, CO and MO received daily topically treatment for 7 successive days. Groups PC and IV were treated with paraffin oil and (DTD) ivermectin. Results showed that: Total disulfide (e.g. disulfide, Dipropyldisulfide, Propenyl propyl disulfide, allyl methyl disulfide) and Trisulfides, Diallyl (e.g. Dipropyl trisulfide) found in garlic oil. Cinnamic acid, Cinnamaldehyede, cinnamat, Caryophyllene, Cinnamyl acetate, Phellanderene, Pinene, Eugenil, and α-Terpinol found in cinnamon oil. Garlic or cinnamon oils and their mixture (5%) were highly efficacious against S. scabiei var. cuniculi larvae as 100 % mortality was reached 24 hrs. with treatment. On the other hand, all mites treated with oils (5 %) and ivermectin double dosage (1%) died 72 hrs. Garlic or cinnamon oils (5%) and their mixture had a good acaricidal effect on the Sarcoptic scabie is similarly to ivermectin (1%) in vitro. In vivo treatment of P. soroptes sp. infections with the essential oil components trans-cinnamic acid resulted in high mite mortality. Rabbits treated with ivermectin injection (IV) or garlic and cinnamon oils topically showed a significant increase in live body weight and feed intake compared with infested and untreated rabbits (PC). While, rabbits treated with garlic and cinnamon improved in live body weight and feed intake compared with those of infested and treated with ivermectin (IV).