Abstract
Two paraproteins (IgM lambda, IgG3 kappa) obtained from a single individual's sera had been previously shown to possess highly similar, if not identical idiotypic determinants. Preliminary structural analysis indicated that the mu and gamma chains belonged to different heavy chain variable region subgroups. Since there is abundant evidence that there is a relationship between the structure of hypervariable regions of immunoglobulin polypeptide chains and their idiotypic specificities, these findings would suggest that this pair of paraproteins may contain one or more identical hypervariable regions within different framework sequences. To test this possibility, their complete amino acid sequence is being undertaken. This publication describes the sequence of the variable region of the mu chain of this pair paraproteins and brings to 10 the total number of completely sequenced human V HIII proteins.
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