Abstract
AbstractRadioactivity in selected tissues was measured 24 and 72 h after a single feeding of DMBA‐3H or 7‐hydroxy‐DMBA‐3H to female Sprague‐Dawley strain rats, aged 50 days. The concentration of radioactivity per gram of mammary tissue 24 h after a single 5‐, 10‐ or 20‐mg dose of DMBA‐3H was equivalent to 3.2, 6.4 and 15.5 μ respectively. The concentration of radioactivity after 20 mg 7‐hydroxy‐DMBA‐3H was equivalent to 4.8 μ of unchanged hydrocarbon. After a single feeding of 5, 10 or 20 mg of DMBA the incidence of breast cancer was 27, 72, and 100% respectively; after 20 mg 7‐hydroxy‐DMBA, it was 45%. These observations indicate that the level of hydrocarbon in mammary fat is one of the critical determinants for induction of breast cancer. In addition to breast cancer, the 7‐hydroxymethyl compound induced nephroblastoma, lung cancer, and leukemia. These observations support the hypothesis that 7‐hydroxy‐DMBA, a metabolite of DMBA, is more closely related to the proximate carcinogen than the parent compound.
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