Abstract

SummaryFactor XIII activity and fibrinogen concentrations were determined in multiple, fresh, platelet-poor plasma samples from 15 species of vertebrates. Factor XIII and fibrinogen levels varied independently. In monkey, rat, cat, horse, pig, sheep, goat, goose, chicken, and turkey plasmas, factor XIII activity ranged from 56 to 96% of that found in human plasma. For guinea pig, rabbit, canine, and bovine plasmas the values ranged from 173 to 480%. Fibrinogen concentration in all species ranged from 2.16 to 4.24 mg/ml. Factor XIII of all species was neutralized to varying degrees by two human antibodies to plasma factor XIII and, except for rabbit and avian plasmas, by rabbit anti-serum to human a subunit. Rabbit antiserum to human b subunit formed a precipitin line with plasma of all species except rabbit and avian.

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