Abstract
Combination of antidepressants from the selective serotonin reuptake inhibitor group (Prozac, Stimulaton) with atypical neuroleptics (Zyprexa, Solian) in patients with recurrent depressive disorder led to weakening of depression by treatment day 10. Depressed mood was the most consistently reduced symptom at each stage of the study (treatment days 10, 20, and 40). Other symptoms had different dynamics, which depended on the treatment given. By the end of the study, treatment results were essentially similar in the study groups. Supplementation of antidepressant treatment with antipsychotics produced a minor increase in the number of adverse reactions.
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