Comparative Studies of Platinum Concentrations in the Neck Tissues of Rats between Intraarterial and Intravenous Infusion of CDDP

Abstract

We studied the comparative pharmacokinetics of platinum between intraarterial and intravenous CDDP infusion in male rats. Platinum concentrations in cervical tissues, serum, and tongue tissues were measured by a single intraarterial infusion or an intravenous infusion at a CDDP dose of 10 mg/kg. Intraarterial infusion was conducted through the left common carotid artery and intravenous infusion through the left external cervical vein. Tissues and blood samples were collected from bilateral sides every 30 minute for 120 minutes after completion of CDDP infusion. Platinum levels in serum showed no significant difference between the 2 routes. Platinum levels in tongue tissue showed a significant difference between the 2 routes favoring of intraarterial administration 30 minutes after infusion. Platinum levels in left cervical tissue following intraarterial administration peaked 90 minutes after infusion, significantly higher than that in right cervical tissue or that following intravenous administration. These findings suggest that CDDP transfers from target organs to neck tissues of the dosage side via the lymphatic duct, and that intraarterial infusion chemotherapy is effective at the target organ and at cervical lymph nodes or cervical tissues.