Abstract
Success in immunizing animals with dead trypanosomes depends on both the method of inactivating trypanosomes and the strain used for immunization. Comparative studies with various inactivating agents showed that β-propio-lactone and formalin are superior to phenol, heat at 56 °C, and lysis in distilled water. A vaccine containing Trypanosoma brucei with frequent passages through mice and not exposed to antibodies could elicit in animals protective antibodies and resistance to a challenge with a homologous strain. Passive immunity was shown in young mice born of vaccinated mothers. On the other hand, no active or passive immunity was demonstrated when animals were immunized with a vaccine prepared from a variant of T. brucei after passage through rabbits or sheep.
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