Abstract
The effects of the octapeptide angiotensin II (AT II) and its analog [Sar 1Ala 8]AT II on the cell density in cell culture from green monkey kidney (GMK) were studied. AT II and [Sar 1Ala 8]AT II provoked a decrease of the number of living cells depending on the concentration (0.001, 0.01 and 0.1 nM) and time of incubation (24, 48 and 72 hours), both peptides having a very similar activity. These data indicate that AT II and [Sar 1Ala 8]AT II may act on the same class of angiotensin receptors in GMK cells.
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