Comparative spectrophoto metric determination of h rip rotidinehydrochloride drug (TPH) using oxidizing agents Potassiumpermanganate & Potassium dichromate

Abstract

This research deals with spectrophotometric method for determination of Triprolidine Hydrochloride drug (TPH) using two different oxidizing agents; Potassium permanganate and Potassium dichromate .The analytical results obtained are as follow :1- The alkaline media (NaOH): Potassium permanganate gives green solution which gives spectrum with amaximum absorption at 612nm its found that optimum conc. for alkaline solution is 1.2X10 'M and 1X10>M for Potassium permanganate within 10 minutes oxidizing time. The statistical and other analytical results for drug concentration range (1-12) ppm are as follows: Correlation coefficient r = 0.9989 , molar absorption coefficient 26993 L/mol.cm and sandel’s sensitivity is 0.0122pg/cm? at Apa =612nm. This method is applied for the determination of TPH in pharmaceutical preparations with percentage recovery not less than 96.22 %. 2-The acidic media (HCI): Potassium dichromate gives yellow solution with amaximum absorption at 350 nm the optimum conc for acidic solution is 1X10% M and 1.5X10°M for Potassium dichromate duringl5 minutes oxidizing time. The statistical and other analytical results for drug concentration range (1-12) ppm are as follows: Correlation coefficient r = 0.9969, molar absorption coefficient 38559.5 L/mol.cm and sandel’s sensitivity is 0. 0086pg/cm? at Amax =350nm This method is applied for the determination of TPH in pharmaceutical preparations with percentage recovery not less than 94.66%.