Abstract
The responsiveness of different regions of the gastrointestinal tract to the competitive antagonists, atropine and methacholine, was studied in segments of rabbit and human tissues. By use of the pA h values for the interaction of these drugs, it could be shown that no regional differences in sensitivity exist between rabbit stomach, ileum, and colon. There were no regional differences in sensitivity between segments of human ileum and colon nor between the species, for these segments of bowel. The circular muscles of the human colon and the human taenia coli were also studied using the cholinergic drugs acetylcholine and methacholine and the competitive antagonist, atropine. There were no differences in the inhibitory action of atropine on these drugs between the two types of muscle. The circular muscle of colon was more sensitive to the stimulatory action of methacholine while the sensitivity to acetylcholine was the same in both types of muscle. The responses of the human tissues were not altered by the nature of the pathology.
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