Abstract
The relative conversion of dehydroepiandrosterone sulfate and 3H-androstenediol- 3-sulfate testosterone to and androstenedione by microsomal preparations of rat testes was studied. In 2 hr, in the presence of DPN, TPN and TPNH, 44% of androstenediol–3-sulfate was converted to testosterone and 29% to androstenedione compared to 15% and 43%,respectively, of dehydroepiandrosterone sulfate. In addition, small amounts of the following 5α reduced steroids were isolated as products of both substrates: epiandrosterone and dihydrotestosterone; from androstenediol–3-sulfate only: androsterone, 5α-androstane-3β,17β-diol and αandrostane- α,17β-diol. The much greater conversion of androstenediol–3-sulfate to testosterone suggests this to be the preferable precursor. The identification of 5α-androstane-3β,17β-diol as a distant product of androstenediol–3-sulfate metabolism is consistent with the previous suggestion that this potent inhibitor of testicular steroid sulfatase may act by feedback inhibition to control the ...
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