Comparative retrospective study of biochemical and haematological biomarkers and their alterations in First and Second COVID-19 wave in a tertiary care facility in Ghaziabad

Abstract

Background: The second wave of COVID-19 in India started in the middle of March 2021. In comparison to the first wave, the second wave of COVID-19 was characterized by a massive increase in the number of cases, reduced supplies of essential treatments, and increased deaths, particularly in the young population. In addition, the second wave was also characterized by the reporting of numerous cases of mucormycosis. Surprisingly, it was the younger population who were more affected in the second wave of the disease. The distinct difference in the first and second waves of COVID-19 in India makes it imperative to study the biochemical and pathological differences between the two. Methods: We aimed to assess the biochemical and pathological biomarkers and their alterations in 1st and 2nd waves of COVID-19 in a tertiary care L3 facility in Ghaziabad. Reports of haematological and biochemical parameters of the admitted patients were compiled retrospectively for statistical analysis based on the severity status of the patient and were compared between the first wave and second wave of COVID-19.