Abstract
Aim. To evaluate the effecacy of enalapril (Enam, Dr.Reddy’s, India) and atenolol (Tenormin, AstraZeneca, UK) and their influence on processes of cardiovascular system remodeling in comparative research in patients with arterial hypertension. Material and methods. 38 patients with arterial hypertension stage II were examined. 21 patients were treated with enalapril (10-40 mg\d) and 17 – with atenolol (50-100 mg\d). Duration of therapy was 24 weeks. A daily monitoring of blood pressure and echocardiography were made before and after the treatment. Spontaneous erythrocyte aggregation and deformability, spontaneous platelet aggregation and adhesive property of neutrophils were also estimated. A number of leucocytes carrying activation markers and expressing adhesive molecules was calculated. The plasma concentration of adhesive molecules (ICAM-1) and von Willebrand protein as well as serum concentration of N-terminal peptide of procollagen type III was also estimated. Results. Enalapril versus atenolol improved blood rheology, reduced functional leucocytes activity, plasma concentration of von Willebrand protein and intercellular adhesive molecules. The reduction in collagen III synthesis activity in enalapril therapy was proved. A significant regress of left ventricle hypertrophy due to enalapril treatment was related with favorable non-hemodynamic effects. Conclusion. The research revealed that the blockage of tissue rennin-angiotensin system is very important in prevention of cardiovascular complications especially in high risk patients.
Highlights
Cравнительное исследование эффективности антигипертензивной терапии эналаприлом и атенололом у пациентов высокого риска О.М.Моисеева, С.В
Material and methods. 38 patients with arterial hypertension stage II were examined. 21 patients were treated with enalapril (10-40 mg\d) and 17 – with atenolol (50-100 mg\d)
A significant regress of left ventricle hypertrophy due to enalapril treatment was related with favorable non-hemodynamic effects
Summary
Cравнительное исследование эффективности антигипертензивной терапии эналаприлом и атенололом у пациентов высокого риска О.М.Моисеева, С.В. У больных артериальной гипертензией оценить в сравнительном исследование эффективность терапии эналаприлом (Энам, Dr.Reddy’s, Индия) и атенололом (Тенормин, AstraZeneca, Великобритания) и ее влияние на процессы ремоделирования сердечнососудистой системы. Определяли концентрацию в плазме адгезионных молекул (ICAM-1) и фактора Виллебранда, а в сыворотке концентрацию N-терминального пептида проколлагена III типа. В отличие от атенолола на фоне эффективной антигипертензивной терапии эналаприлом выявлено улучшение реологических свойств крови, снижение функциональной активности лейкоцитов, а также концентрации фактора Виллебранда и межклеточных адгезионных молекул в плазме крови. Подтверждено снижение активности синтеза коллагена III типа при терапии эналаприлом. С положительными негемодинамическими эффектами эналаприла был связан больший регресс гипертрофии левого желудочка в процессе лечения. Ключевые слова: артериальная гипертония, эналаприл, атенолол, реология крови, адгезивные молекулы, коллаген III типа. To evaluate the effecacy of enalapril (Enam, Dr.Reddy’s, India) and atenolol (Tenormin, AstraZeneca, UK) and their influence on processes of cardiovascular system remodeling in comparative research in patients with arterial hypertension
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