Abstract
1. 1. The rate of metabolism of pipecolic acid, measured in liver and kidney, varied 1000 fold among 10 animal species. Degradation of l-pipecolic acid by kidney in rat and mouse was 0.11 and 0.31 pmoles/min/mg protein, respectively; in monkey and human, 3.0 and 6.5; in guinea-pig and rabbit 101 and 106. 2. 2. Activity with d-pipecolic acid was consistently 50–60% higher than the l-isomer except in the rabbit. 3. 3. Degradation of l-lysine, presumably through the saccharopine-α-aminoadipic acid pathway, was effective in all species, contrasting with the variable performance in the pipecolic acid-α-aminoadipic acid pathway.
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