Comparative Quality Evaluation of Different Brands of Albendazole Tablets Marketed in India

Abstract

Anthelmintic drugs are primarily used to treat parasitic infections. More than 1.5 billion individuals, or 24% of the world's population, were estimated to be infected by soil-transmitted helminths. Pharmaceuticals are essential for preserving human health and fostering happiness. However, it is vital to determine the drug's safety, efficacy, and quality to provide the intended pharmacological effect. The drugs must have the necessary physical properties and the correct quantity of active pharmaceutical ingredient (API) to be effective. The quality of various brands of albendazole tablets sold in India was assessed qualitatively and quantitatively in this study. The current study aims to investigate the physicochemical comparability of three different brands of albendazole containing tablets obtained from several retail pharmacies in Agra, Uttar Pradesh, India. The Indian Pharmacopeia standards were used as a control to evaluate the identity and content of the API in the tablets. The tablet’s uniformity of weight, friability, hardness, thickness, rate of dissolution, and content analysis were assessed using an assay. Ultraviolet-Visible Spectroscopy (UVS) was used to identify and evaluate Indian Pharmacopoeial standards. All in vitro evaluation tests showed that all three tablet brands complied with the Indian Pharmacopoeial standards. The quantity of albendazole released from the various brands did not differ noticeably. These findings showed that the tablets of albendazole sold in retail stores in Agra are produced and marketed by Indian firms that have received WHO-GMP certification. On the bioequivalence of these tablets, more research is suggested. Keywords: Albendazole Tablet, Indian Pharmacopoeia, WHO-GMP, Physicochemical Equivalence, In-Vitro Evaluation