Abstract
Abstract Purpose: Radiation therapy with protons, owing to its physical properties, can be advantageous for the treatment of children. This study was conducted in order to quantify the advantages of proton therapy from a treatment planning point of view in a consecutive, realistic, and mixed pediatric/adolescent population with varying diagnoses and target locations. Patients and Methods: Forty-five patients treated with conventional 3-dimensional conformal radiation therapy photon radiation therapy were retrospectively re-planned with scanned proton beams. Treatment sites represented were the central nervous system, head and neck, thorax, and abdomen. Median age was 8 years (range, 2-18 years). All plans were optimized with intensity-modulated proton therapy (multi-field optimization). We analyzed a number of dose-volume descriptors for planned target volumes (PTVs). Organ-specific mean doses and relevant DV -values were derived for organs at risk. In addition, homogeneity index, conformity index, treate...
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