Abstract
1. Cytochrome P-448 from β-naphthoflavone treated rainbow trout ( Salmo gairdnerii) liver was purified and compared to purified P-448 from β-naphthoflavone treated rats ( Rattus rattus) and purified P-450 from phenobarbital induced rats. 2. The two P-448 forms had similar spectral properties, substrate specificity, sensitivity to inhibitors and regioselectivity in the metabolism of benzo(a)pyrene and testosterone. 3. Rat and trout P-448 differed in apparent monomeric mol. wt (M r) by at least 2000 daltons, and did not share identical antigenic determinants. Both rat and trout P-448 were shown to be quite different from rat P-450 using all of the above criteria for distinguishing multiple forms.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Comparative Biochemistry and Physiology. Part C, Comparative Pharmacology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
