Abstract
Objectives: To examine the kinetics of the disposition of Plasmodium falciparum during treatment with amodiaquine, a Mannich base derivative of chloroquine and chloroquine. Additional aims were to compare P. falciparum kinetics in children in whom initial treatment with chloroquine failed and following re-treatment with amodiaquine, and in siblings in whom there was household clustering of falciparum infections. An important aim was to validate the kinetic method of evaluating therapeutic efficacy in a randomised trial involving the antimalarial drugs amodiaquine and chloroquine.
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