Abstract
The present study was undertaken to explore the comparative phytochemical analysis and immunomodulating activities of various successively extracted leaf extracts of Stevia rebaudiana (Bertoni) in albino rats. Phytochemical screening conducted on various organic leaf extracts of S. rebaudiana revealed the presence of several biologically active molecules that include sterols, saponins, alkaloids, glycosides, phenols, tannins, flavonoids and resins. The immunomodulatory activities were determined by neutrophil adhesion test, haemagglutination antibody (HA) titre delayed type hypersensitivity (DTH) response and phagocytic activity. The response produced by oral administration of ethanolic and aqueous leaf extracts showed a significant increase in neutrophil adhesion and DTH response. The augmentation of humoral immune response to sheep red blood cells by ethanolic and aqueous extracts at 300–500 mg kg–1 was higher than when an extract dose of 200 mg kg–1 was used, as shown by a dose-related increase in antibody titres in experimental rats. This study demonstrates potent immunomodulatory activities and therapeutic potential of phytochemical compounds extracted from S. rebaudiana leaf to combat against immunological disorders.
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