Abstract
A reanalysis of the sequences reported by Hoegg et al has highlighted the presence of a putative HoxC1a gene in Astatotilapia burtoni. We discuss the evolutionary history of the HoxC1a gene in the teleost fish lineages and suggest that HoxC1a gene was lost twice independently in the Neoteleosts. This comment points out that combining several gene-finding methods and a Hox-dedicated program can improve the identification of Hox genes.
Highlights
The identification of individual Hox genes is an essential basis for their study in evolutionary research fields
HoxC1a gene detection Astatotilapia burtoni Hox cluster genomic sequences were collected from GenBank and submitted to the de-novo gene prediction program GENSCAN [3]
Combined with the detection of HoxC1a orthologs in G. aculeatus and F. heteroclitus, we introduce here a more comprehensive set of HoxC1a genes in teleosts
Summary
The identification of individual Hox genes is an essential basis for their study in evolutionary research fields. Hoegg et al [1] present the Hox gene content of the cichlid fish Astatotilapia burtoni, characterized from the complete sequence of the seven Hox clusters. We complement the analysis of the Hox gene content of Astatotilapia burtoni reported in [1], using a combination of sequence similarity methods, de-novo gene predictions and a program we have developed that classifies Hox proteins in their homology groups [2]. We collect a comprehensive set of HoxC1a sequences that allows us to re-investigate the presence of HoxC1a pseudogenes in various teleost species.
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