Comparative pharmacological and phytochemical investigation on the wound-healing effects of the frequently used essential oils

Abstract

Essential oils from several plants have been used for the first aid treatment of wounds, abscess, and burns. For this reason, we aimed to evaluate the wound-healing potential of some essential oils, obtained from Pimpinella anisum L., Eugenia caryophyllus (Spreng.) Bullock & S.G. Harrison, Cuminum cyminum L., Foeniculum vulgare Mill., Laurus nobilis L., Lavandula angustifolia Mill. ssp. angustifolia, and Melissa officinalis L., that have been frequently used in aromatherapy. In the present study, in vivo wound-healing activities of the selected essential oils were investigated by using linear incision and circular excision wound models. Moreover, the oils which are active in these test systems were analyzed by GC/MS for the identification of the major components. Essential oil obtained from L. angustifolia ssp. angustifolia and L. nobilis were found to be the most active among the tested samples. This research confirms the traditional usage of the active oils.