Comparative Pharmacokinetics––sorting the sheep from the goats

Abstract

Goats (caprine) and sheep (ovine) are infected with the same principal gastrointestinal nematode (GIN) species, which provoke similar pathological changes and economic consequences. However, until now, the majority of data on host–parasite interactions have been accumulated from ovine studies. This article aims to emphasize the need for specific caprine studies. It is hypothesized that, owing to divergent evolutionary processes, sheep and goats have developed two different strategies to regulate GIN infections, respectively, based on immune response versus feeding behavior. Generation of additional comparative data should result in a better understanding of the possible trade-offs between these two basic regulatory processes. Goat studies should also help to avoid past errors in the control of GIN species owing to the lack of relevant information.