Abstract
Objective: Reliadol® (Nycomed Denmark A/S) is a new modified-release morphine formulation undergoing clinical evaluation. It consists of a mixture of rapid- and modified-release microencapsulated granules of morphine. The study aims were to investigate the single-dose pharmacokinetics of morphine, its metabolites morphine-6-glucuronide (M6G) and morphine-3-glucuronide (M3G), after ingestion of Reliadol® (2 × 30mg capsules) compared with Kapanol® (3 × 20mg) [Glaxo Wellcome Australia Ltd] and an immediate-release morphine tablet (Morfin ‘DAK’, 30mg; Nycomed Denmark A/S).
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