Comparative pharmacokinetics of diaveridine in pigs and chickens following single intravenous and oral administration.

Abstract

Comparative pharmacokinetic profiles of diaveridine following single intravenous and oral dose of 10mg/kg body weight in healthy pigs and chickens were investigated, respectively. Concentrations of diaveridine in plasma samples were determined using a validated high-performance liquid chromatography-ultraviolet (HPLC-UV) method. The concentration-time data were subjected to noncompartmental kinetic analysis by WinNonlin program. The corresponding pharmacokinetic parameters in pigs or chickens after single intravenous administration were as follows, respectively: t1/2β (elimination half-life) 0.74±0.28 and 3.44±1.07h; Vd (apparent volume of distribution) 2.70±0.99 and 3.86±0.92L/kg; ClB (body clearance) 2.59±0.62 and 0.80±0.14L/h/kg; and AUC0-∞ (area under the blood concentration vs. time curve) 4.11±1.13 and 12.87±2.60μg∙h/mL. The corresponding pharmacokinetic parameters in pigs or chickens after oral administration were as follows, respectively: t1/2β 1.78±0.41 and 2.91±0.57h; Cmax (maximum concentration) 0.43±0.24 and 1.45±0.57μg/mL; Tmax (time to reach Cmax ) 1.04±0.67 and 3.25±0.71h; and AUC0-∞ 1.33±0.55 and 9.28±2.69μg∙h/mL. The oral bioavailability (F) of diaveridine in pigs or chickens was determined to be 34.6% and 72.2%, respectively. There were significant differences between the pharmacokinetics profiles in these two species.