Comparative pharmacokinetics of cefquinome following intravenous and intramuscular administration in goats

Abstract

The comparative pharmacokinetic profile of cefquinome following single intravenous (IV) and intramuscular (IM) administration of 2mg/kg bodyweight was investigated in goats to determine the potential dosage regimen against susceptible microorganisms. Plasma concentrations of cefquinome were determined by high performance liquid chromatography. Plasma cefquinome disposition followed two-compartmental and mono-compartmental open models after IV and IM injection, respectively. Following IV injection, the major pharmacokinetic parameters (mean±SEM) were t½α 1.17±0.22h, t1/2β 5.76±0.19h, Vd(area) 0.51±0.05L/kg, AUC 33.83±2.53μg/mL, ClB 0.06±0.004L/h/kg and MRT 6.09±0.11h. After IM administration, the principal pharmacokinetic parameters (mean±SEM) were, Cmax 4.84±0.23μg/mL, Tmax 1.5h, t½kα 0.64±0.23h, t½β 5.86±0.29h, AUC 19.82±2.07μgh/mL and MRT 8.08±0.50h. The bioavailability after IM injection was 57.39±3.40%. A dosage regimen of 2mg/kg body weight at 24h interval following IV or IM injection would maintain the plasma levels required to be effective against the bacterial pathogens with MIC values≤0.39μg/mL.