Abstract
A comparative preliminary pharmacokinetic study of two buspirone preparations, Buspar and Spitomin, was performed after a single 10-mg oral dose as a pilot study in beagle dogs. The buspirone levels of blood sample series taken at 13 different times were determined by gas chromatography-mass spectrometry. For the bioanalytical analysis a new type of tetradeuterated buspirone was synthesized as an internal standard. The pharmacokinetic analysis of the concentration-time curves was carried out by the two-compartment open model. Good agreement of the all pharmacokinetic parameters obtained strongly suggests the pharmacokinetic equivalence of the two preparations.
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