Abstract
Objective: To establish comparative pharmacognostic, phytochemical and biological evaluation parameters between five Chlorophytum species i.e. Chlorophytum borivilianum Santapau and Fernades, Chlorophytum comosum (Thunb.) Jacq., Chlorophytum tuberosum Br., Chlorophytum laxum R. Br. and Chlorophytum arundinaceum Baker, of very popular Ayurvedic plant Safed Musali. Materials and methods: Comparative evaluations of Macro and microscopical, physico-chemical parameters of tubers of all five species were investigated and preliminary phytochemical analysis, estimation of major phytochemicals and TLC profiles were also carried out for qualitative phytochemical evaluation. In-vitro antioxidant and anticancer activity was carried out for extract of tubers of all five species. Results: Macro, micro, powder microscopical parameters of tubers of five species were examined and recorded the result. Tubers of all the five species are distinct in their morphology as well as anatomical characters. Physicochemical characters (Ash values, Loss on drying (LOD), swelling index and foaming index) as well as total saponin content shows great variability among five species. Results of In-vitro antioxidant by DPPH method shows difference in antioxidant potential between tubers of all five species. Extract of tubers of all five species do not show any type of In-vitro anticancer activity by SRB method against HL 60 leukemia cell line. Conclusion: All of the evaluated parameters are very good pharmacognostic standards for future comparative identification and authentication of specific species because all five species shows morphological, anatomical, chemical differences as well as varies in antioxidant potential.
Highlights
A number of species belonging to the genus Chlorophytum are noted for their medicinal benefits in Ayurvedic, and Unani system of medicine are popularly known as safed musli.[1]
Methanolic extract of C. borivilianum, C. comosum, C. laxum, C. tuberosum and C. arundinaceum are subjected to thin layer chromatography to confirm the presence of saponin
Total five species of Chlorophytum i.e. borivilianum, tuberosum, laxum, comosum and arundinaceum were collected from different locations and identified as well as authenticated from Dr Prabha Bhogonkar, Ex-HOD, Botany, Vidarbha Institute of Science and Humalities College, Amravati and Dr Arvind S
Summary
Safed musli is very popular Ayurvedic drug and ingredient of many herbal formulations. There are almost 215 species that have been reported in the genus Chlorophytum. Incorrect identification affects quality and efficacy of medicinal products containing this plant. Evaluated parameters in this work are very good pharmacognostic standards for future comparative identification and authentication of specific species
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