Abstract
The radiopaque dicalcium silicate cement (RDSC) displayed a shortened setting time and good biocompatibility. This study aimed to compare the regenerative potential of RDSC and white-colored mineral trioxide aggregate (WMTA) using a rabbit femur model. The animals were sacrificed at one, three and six months to accomplish histological and biochemical analyses. The results indicated that after one month of implantation, WMTA was associated with a greyish color alteration within its mass, while RDSC presented color stability even at six months. Histological assay with Masson’s Trichrome and Von Kossa stains showed the presence of newly formed bone surrounding the implanted sites in the rabbit femur. The histochemical data revealed that the RDSC group had significantly more bone regeneration than did the WMTA groups at three and six months. The conclusion drawn is that the encouraging results support the potential applications of RDSC as an improved alternative to WMTA for endodontic uses.
Highlights
Calcium silicate-based mineral trioxide aggregate (MTA) has been successfully used in endodontic treatment because of excellent biocompatibility, sealing ability and regenerative capabilities as well as antibacterial properties [1,2]
Cement (RDSC) could set within 24 min when mixed with water, which the setting time was significantly lower than that of ProRoot white-colored mineral trioxide aggregate (WMTA) (168 min)
It has been found that radiopaque dicalcium silicate cement (RDSC) has high in vitro apatite-forming ability and low degradation [9]; it may be an alternative to WMTA
Summary
Calcium silicate-based mineral trioxide aggregate (MTA) has been successfully used in endodontic treatment because of excellent biocompatibility, sealing ability and regenerative capabilities as well as antibacterial properties [1,2]. Cement (RDSC) could set within 24 min when mixed with water, which the setting time was significantly lower than that of ProRoot white-colored mineral trioxide aggregate (WMTA) (168 min). It has been found that RDSC has high in vitro apatite-forming ability and low degradation [9]; it may be an alternative to WMTA. Exposure of bioactive material surfaces such as MTA and calcium silicate to a physiological solution elicits the precipitation of a “bone-like” apatite layer, which may support the material’s ability to integrate into living tissue [10,11,12]. A synergistic effect between Si as an effective apatite nucleator and Ca as an apatite precipitation accelerator could cause an apatite precipitation [10]
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