Comparative Neuroprotective Effect of Energy Drinks

Abstract

Objective: The objective of this research was Comparative neuroprotective effect of energy drinks inmice using various experimental animal models.Method: The Tail suspension test (TST), Forced swim test (FST) and Y-maze test were used to assessthe antidepressant activity of the Energy drinks (Red bull, monster and enerzal) in mice. In addition,attempts have been conducted to explore the level of brain monoamine neurotransmitters like Dopamineand Serotonin using flame fluorimeter.Result: The study of energy drinks on the gross behaviour of mice indicated their CNS antidepressanteffect. Furthermore, their significant (p<0.0001) antidepressant property was estimated by obtainingits decreased immobility time of mice in tail suspension and forced swim tests. It has also exhibitedsignificant cognitive property performed in Y-maze apparatus. Biochemical study showed theirpotentiation in the brain dopamine and serotonin concentration significantly (p<0.001) in mice whichconcludes the mechanism behind their CNS depressant and cognitive propertiesConclusion: The gross behavioural study indicated their antidepressant potentiality which was furtherconfirmed by conducting FST and TST. Further the study showed the memory enhancement by theEDs using Y-maze apparatus but in lesser extent. Antidepressant drugs are well evident with propertyto increase dopamine and serotonin level and EDs were observed to potentiate significantly the braindopamine and serotonin concentration in mice.