Abstract
Pancuronium, gallamine, and succinylcholine produced more profound neuromuscular blockade in 36 patients anesthetized with 1.25 MAC Forane than in 36 patients anesthetized with 1.25 MAC halothane. The median effective dose of pancuronium necessary to produce 50 per cent depression of twitch height (ED20) was 0.27 mg/m2 during Forane and 0.49 mg/m2 during halothane anesthesia, giving a halothane/Forane potency ratio of 1.8. The ED20 of gallamine was 9.4 mg/m2 during Forane anesthesia and 22.5 mg/m2 during halothane anesthesia, for a potency ratio of 2.4. The ED20 of succinylcholine was 3.4 mg/m2 during Forane anesthesia and 5.1 mg/m2 during halothane anesthesia, for a potency ratio of 1.5.
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