Abstract
Neonicotinoid baits are recently replacing anticholinesterase baits for adult house fly (Musca domestica L.) control. Recently, imidacloprid (IMI) and thiamethoxam (THIA) are widely used for the control of this pest. In this study both compounds were docked to elucidate their interactions with acetylcholine binding protein (AChBP). The feeding technique was used to evaluate the toxicity of tested insecticides to adult house flies. Bioassay experiments showed that the THIA was more toxic to adult house flies than IMI with LC50 values 7.27 and 21.08 ppm; respectively. The biochemical activities of acetylcholinesterase, ATPase, cytochrome P-450 and carboxylesterase were increased by insecticides treatment, while, the total protein content was reduced.
Highlights
The use of insecticides is very important for the control of house fly (Musca domestica L.), in spite of their ability to develop resistance to these insecticides with long term exposure
The previously mentioned data revealed that the THIA showed higher toxicity to adult house flies than IMI
It was noticed that the expected toxicities of IMI and THIA obtained from insecticides docking to the simulating enzyme vary from the experimental toxicity results
Summary
The use of insecticides is very important for the control of house fly (Musca domestica L.), in spite of their ability to develop resistance to these insecticides with long term exposure. THIA and IMI provide excellent effect against a broad range of insects with sucking and chewing habits Jeschke and Nauen (2008) such as leaf miners as well as some lepidopterous species, aphids, Colorado potato beetle, whiteflies, fleas, beetles, wireworms, rice hoppers and thrips Abdallah et al (2016). They are extensively used in control of insect
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