Abstract
Using a capillary tube migration technique, a comparison was made between the random mobility of separated guinea pig T- and B-lymph node lymphocyte subpopulations, and macrophage-rich peritoneal exudate cells. A decrease in random movement was found in that order, which would fit with the hypothesis that migration on a substrate is an adherence-dependent phenomenon. In order to characterize a possible dichotomy between T-and B-cell locomotion, the effects of several factors which might interfere with their migration were studied. These factors included drugs which affect cell metabolism, cell surface ligands, and some factors which may play a role in inflammatory foci (acidity, immune complexes, and lymphokines). The results emphasize the similarity in the mode of locomotion of T and B lymphocytes. However, a remarkable difference was found in the stronger inhibition of B-cell migration by pH values below pH 7.0. The relevance of these findings to the migration of T and B lymphocytes into inflammatory foci is discussed.
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