Abstract
Investigation of mucosa immunoglobulin A (IgA) can be used to determine the prevalence of <i>Chlamydia trachomatis</i> (CT) infection, in addition to examination of <i>Polymerase Chain Reaction</i> (PCR) particularly in asymptomatic cases. This research is aimed to compare the levels of IgA mucosal urethral in asymptomatic <i>Chlamydia trachomatis</i> infection and non-infection in male prisoners based on PCR examination in the prison. The methods used was urethral swab specimens collected from 43 asymptomatic male prisoners at the Sidrap Prison in December 2015 and then were examined using PCR method, followed by examination of mucosal IgA levels. The results indicate prevalence of CT based on PCR examination is 2.3%. Based on the examination of PCR, mucosal IgA levels in infected by CT six-fold higher than non-infectious with a mean ± SB (4.45) vs (0.77 ± 0.52) with p = 0.09. Based on the examination of mucosal IgA, the level of infected IgA is four-fold higher than non-infectious with a mean ± SB (2.48 ± 1.41) vs (0.64 ± 0.21), with p < 0.001. The combination of a positive PCR results and/or IgA positive with urethral specimen indicate infection of CT, but PCR and IgA in CT infections are not interchangeable but both constitute complementary examination.
Highlights
Chlamydia trachomatis (CT) is the most common cause of sexually transmitted infections (STIs) caused by Chlamydia spp. which is an obligate intracellular bacterium that require living cells to proliferate. [1] CT infection is known as a silent disease because infected individuals are asymptomatic
[3] Immunoglobulin A (IgA) produced by plasma cells found in large numbers in endocervical and urethral penis
Chlamydia trachomatis Infections in the Prison results and negative IgA obtained as many as 38 samples with a mean of 0.64 and p < 0.002
Summary
Chlamydia trachomatis (CT) is the most common cause of sexually transmitted infections (STIs) caused by Chlamydia spp. which is an obligate intracellular bacterium that require living cells to proliferate. [1] CT infection is known as a silent disease because infected individuals are asymptomatic. [1] CT infection is known as a silent disease because infected individuals are asymptomatic. If these individuals are not diagnosed and not given treatment, they become a reservoir of the disease and will lead to longterm complications. [2] There are approximately 50% of asymtomatic CT infection of the urethra in men. Asymtomatic of CT infections in men lead to urethritis, proctitis, epididymitis, can even cause infertility. [3] Immunoglobulin A (IgA) produced by plasma cells found in large numbers in endocervical and urethral penis. Diagnosis based on clinical symptoms and laboratory tests. If there is no clinical symptoms but there are risk factors, should be suspected infection C.trachomatis and laboratory tests should be performed. The criteria for the risk in question is sexual partners more than once in the past month, have sex with female sex workers in the last 1 month, American Journal of Clinical and Experimental Medicine 2016; 4(2): 30-33 experiencing one or more episodes of sexually transmitted diseases in the last 1 year and work wives or sexual partners at high risk. [4]
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