Abstract
COSTEAS, A., WOODARD, H. Q., AND LAUGHLIN, J. S. Comparative Kinetics of Calcium and Fluoride in Rabbit Bone. Radiat. Res. 46, 317-333 (1971). The comparative short-term kinetics of calcium and fluoride in rabbit tibias were studied by means of 47Ca and 18F. Correction was made for isotope present in vascular spaces. The uptake of both isotopes was greater in the epiphyses and metaphyses than in the diaphyses. The uptake of 18F was always greater than that of 47Ca, but the relative uptake of the two isotopes was the same in different parts of the bone. The ratio of the sizes of the exchangeable pools of the two elements was comparable to the ratio of their natural abundances in bone. In cortical bone the uptake of isotope was related linearly to a part of the water content. Treatment with parathyroid hormone resulted in a 60 % increase in uptake of '8F and a 25 % increase in the size of the exchangeable pool of fluoride. Nearly half of the total 47Ca activity recorded by external counting over the intact leg during the first 4 hours was in the soft tissues, while the
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