Abstract
The use of plants and plant products as medicines could be traced as far back as the beginning of human civilization. Pakistan has a great wealth of Z. armatum which has valuable use as oil not only in Pakistan but all over the world. The present study was carried out in vitro to determine Comparative activity of Z. armatum leaf extracts against Pathogenic bacterial strains by using leaf Hot water and Ethanol extracts. Antimicrobial activity of Z. armatum was evaluated by well diffusion methods. The highest zone of inhibition produced by Ethanol extract as compared to Hot Water. Escherichia coli 15mm and 2 mm, Enterococcus faecalis 14mm and 2 mm, Pseudomonas aeruginosa 33 mm and 3 mm, Klebsiella pneumoniae 28 mm and 2mm, Staph. Aureus 12 mm and 2 mm and Salmonella typhimurium 28 mm and 2 mm on Ethanol and Hot water extract respectively. This study concludes that Ethanol extract has more effect then Hot water extract and further work should be done to investigate and find out the active Chemical compounds responsible for the biological activity and to find out the accurate mechanism of action by which extracts exert their antimicrobial effect to recognize which can be used in drug development for safe health care services.
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