Comparative Hepatoprotective and Haematological Effects of the Ethanol Extracts of the Leaves of Vitex Doniana and Senna Occidentalis in Alloxan-Induced Diabetes in Male Wistar Rats

Abstract

Aim The goal of this study is to determine the Antidiabetic and hepatoprotective effects of the ethanol extracts of the leaves of Vitex doniana and Senna occidentalis in alloxan induced diabetes in male Wistar rats Materials and methods Thirty male albino rats were randomly divided into five groups consisting of six animals each Diabetes was induced using intraperitoneal administration mg kg body weight of alloxan and treatment was carried out over a period of days The first group served as the normal control and received only normal feed and water Group diabetic rats without treatment Group diabetic ratstreated with mg kg ethanol extract of Vitex doniana Group diabetic rats treated with mg kg ethanol extract of Senna occidentalis And group diabetic rats treated with mg kg Glibenclamide Results Glucose level Thiobarbituric acid reactive substances TBARS bilirubin alanine aminotransferase aspartate aminotransferase and full blood count were significantly p lt changed in rats treated with Alloxan mg kg bw while treatment with the respective extracts significantly changed the levels of these parameters to normal The results obtained indicate that the extracts were beneficial in ameliorating damages caused by Alloxan in male rats Conclusion This study clearly showed the hepatoprotective and haematological effects of the ethanol extracts of the leaves of Vitex doniana and Senna occidentalis in alloxan induced diabetes in male Wistar rats The obtained results indicated that Vitex doniana and Senna occidentalis at about g bw would be a good natural source for protection against diabetes induced liver and blood toxicities