Comparative growth dynamics of bacterial and fungal contaminants in liposomal bupivacaine, bupivacaine 0.5%, and propofol

Abstract

Introduction: Bupivacaine liposomal injectable suspension (BLIS) provides local analgesia for up to 72 hours. Multiple vial punctures over consecutive days have been suggested as a cost-effective, extra-label handling strategy. It is unknown, however, if BLIS supports microbial growth when extrinsically contaminated.